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KMID : 0370220030470040195
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Yakhak Hoeji
2003 Volume.47 No. 4 p.195 ~ p.199
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Analysis of 3,4-Methylenedioxymethamphetamine (MDMA) in Human Hair by Gas Chromatography/Mass Specirometry
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박미정
김은미/임미애/정희선
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Abstract
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An analysis method for the determination of methylenedioxymethamphetamine (MDMA) and its metabolite methylenedioxymethamphetamine (MDMA) in hair by gas chromatography/mass spe ctrometry was proposed. For MDMA and MDA analysis, hair samples were incubated in MeOH (1% HCl), derivatized with trifluoroacetic anhydride and assayed by GC/MS. Hair of 18 subjects for drug abuse was analysed for MDMA and MDA. Calibration curves for the determination of MDMA and MDA in hair showed a good linearity at a concentration range from 0.5 ng to 250 ng (r2=0.999) The extraction recovery was determined from hair blanks at 50, 100 ng. The percentage of recovery were found to be 96.08~103.48 with CV value of 1.62~3.89. The concentrations of MDMA and MDA ranged 1.14~38.06 ng/mg and 0.07~3.91 ng/mg, respectively in 18 hair samples from MDMA abusers. The ratio of MDMA to MDA ranged from 9.65~28.46 in all specimen. Hair analysis for MDMA is a useful method for identification of long-term drug abuser.
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